What should I know about Prolia vs. Fosamax? Patients should not stop Prolia treatment without first consulting your For instance: Both Prolia and Forteo are given as injections under your skin. If youre concerned about side effects with Prolia, talk with your doctor. Denosumab is contraindicated in women with hypocalcaemia. Cleveland Clinic is a non-profit academic medical center. We avoid using tertiary references. Prolia contains the active ingredient denosumab. Prolia 60 mg/1 mL in a single-dose prefilled syringe (medicine). If the user is trying to grow bone due to osteoporosis, osteopenia, or any reason, the recommended intake is 4 capsules divided into 2 doses also taken in the morning and evening with food. Factors to consider include those in the list below. But, in some cases, alcohol can affect your balance and increase your risk for falls. It does the same thing that. Keep in mind that side effects of a drug can depend on: Additionally, you may experience different side effects from those listed below based on the condition youre treating with Prolia. Tell your doctor if you become pregnant. Compared to other osteoporosis treatments, only Proliais1 shot every 6 months. (Biosimilars are like generic drugs. WebTake calcium and vitamin D as directed by your doctor, usually 1000 milligrams of calcium and at least 400 IU of vitamin D daily. If you keep this medicine at home, store it in the original carton in a refrigerator. for breast cancer that has not spread to other parts of the body. Xgeva is also used to treat giant cell tumor of the bone. If your pain is more severe, your doctor may suggest prescription pain medication or physical therapy. These factors include what your insurance plan covers. Your risk of bone fractures can increase when you stop, skip or delay using Prolia. MEDICATION GUIDE Prolia (PR-lee-a) (denosumab) To learn more about this, see the How is Prolia administered? section below. Prolia contains the active drug denosumab, and Reclast contains the active drug zoledronic acid. Some people may have an allergic reaction to Prolia. Find out what it means, how its calculated, and more. By stopping RANKL from binding to its receptor Prolia reduces bone breakdown, bone loss, bone pain, and other bone complications. These medications have different active ingredients and they belong to different groups of drugs. Mild side effects can occur with Prolia use. Muscle pain often contributes to back pain, one of the most common side effects reported in clinical trials of Prolia. Common side effects of Prolia can vary depending on which condition the drug is being used to treat. You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Q: Does AlgaePlus Increase Bone Mass? Before taking Prolia, tell your doctor about all of your medical conditions, including if you: Your healthcare provider should do a pregnancy test before you start treatment with Prolia. This can cause your weight to change and may explain any weight gain since starting Prolia treatment. Its given to adults who are at high risk for bone fractures. They can treat the infection as needed. Mild side effects that have been reported with Prolia include: These side effects may be temporary, lasting a few days or weeks. For women with osteoporosis after menopause at high risk for fracture. See additional information. They may help you identify other possible causes or suggest ways to help manage hair loss. While youre taking Prolia, your healthcare provider will also strongly suggest taking at least 1000 mg of calcium and 400 international units (IU) of vitamin D daily to prevent hypocalcemia or low calcium levels. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. For this reason, some calcium supplements are combined with vitamin D. This vitamin is available in two forms, vitamin D 2 (ergocalciferol) and vitamin Your doctor should examine your mouth before you start Prolia and may tell you to see your dentist. * For more information on this side effect, see the Side effect focus section below. You should also talk with them if you have any serious side effects during Prolia treatment. Your doctor can also help you decide if the benefits of Prolia treatment outweigh your risks of side effects. If you receive Prolia, you should not receive XGEVA. It works with your immune system to help prevent bone loss. Get the treatment that fits your lifestyle, Stay informed with courtesy reminders, recipes and so much more. People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Call your doctor at once if you have: new or unusual pain in your thigh, hip, or groin; severe pain in your joints, muscles, or bones; skin problems such as dryness, peeling, redness, itching, blisters, bumps, oozing, or crusting; or. you Theres no information available to know whether Prolia is passed into breast milk or if its safe to take while breastfeeding. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Musculoskeletal pain from Prolia is mild or manageable for most people. This is because its not known if Prolia is safe to receive while breastfeeding. You should also talk with your doctor if you have nausea during treatment. You should not receive Prolia if you are allergic to denosumab, or if you Keep in mind that Prolia is used to help strengthen your bones and prevent fractures, which may happen with falls. Prolia Injection (Denosumab): Uses & Side Effects If you develop a side effect while taking Prolia and want to tell the FDA about it, visit MedWatch. such as inflammation of your skin (dermatitis), rash, and eczema have been reported. Your doctor may also recommend other treatments with Prolia to help increase your bone mass. Youll receive Prolia doses from a healthcare professional. Monoclonal antibodies are made to target and destroy only certain cells in the body. Do not stop using this medicine without first talking to your doctor. Its recommended that calcium and vitamin D supplements be taken What should I know about Prolia vs. Zometa? Your body needs calcium to build and maintain strong bones. Your heart, muscles and nerves also need calcium to function properly. Some studies suggest that calcium, along with vitamin D, may have benefits beyond bone health: perhaps protecting against cancer, diabetes and high blood pressure. You should always consult your doctor or another healthcare professional before taking any medication. Use of the terms female and male in this article refers to sex assigned at birth. This includes proper brushing, flossing, mouthwash use, and regular professional dental cleanings. The fractures may require surgeries, take several months to heal, or both. Side effects that you should report to your doctor or health care professional as soon as possible: Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): This list may not describe all possible side effects. Learn more about the unique risk factors for osteoporosis in, Osteoporosis weakens bones, which leads to breaks in the hips, wrists, and spine. If your doctor says this is safe for you, youll be shown how to inject the medication. What should I know about Prolia vs. Tymlos? These lists dont include all possible side effects. If you notice any tooth or jaw pain, or sensitivity while using Prolia, talk with your doctor or dentist right away. Call your doctor for medical advice about side effects. People need calcium for bone health and other functions. Prolia has active ingredients of denosumab. Examples of conditions Prolia is used off-label to treat include: Prolia is one option available to treat osteoporosis and reduce bone loss in people with a high risk for bone fracture. Let your doctor know if you have questions about which drug is recommended for you. Its not known if Prolia is safe or effective for use in children. Learn about compression fractures, preventive medications, and, Preventing osteoporosis can help you prevent fractures and maintain strength as you age. Also tell them if you smoke, drink alcohol, or use illegal drugs. You should not take Prolia if youve ever had an allergic reaction to Prolia or any of its ingredients. Osteoporosis Medications (Bisphosphonates) - Johns Hopkins They might also recommend physical therapy, massage therapy, or using a heating pad. Vertigo (dizziness) was reported in some females* using Prolia for osteoporosis. Theyll also discuss with you how to lower your risk for fractures by adding other treatments or making certain lifestyle or diet choices. In fact, bone breakdown is higher in the first several months after you stop Prolia. WebProlia is used to treat osteoporosis in women after menopause and in men, and in people Boniva contains the active drug ibandronate, but Prolia contains the active drug denosumab. Prolia is a prescription medicine used to increase bone mass in men with osteoporosis who are at high risk for fracture. Personalize this study to your gender and age, Arthrotec and Alanine Aminotransferase Increased, Capecitabine and Lumigan drug interaction, Cyramza and Gastrointestinal Stoma Necrosis, Simponi Aria and Pennsaid drug interaction, Docetaxel and Infection In An Immunocompromised Host, Ketorolac Tromethamine and Bladder Obstruction, Roxicodone and Caspofungin Acetate drug interaction, Ginkgo and Nitrofurantoin drug interaction. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Please know that the sponsors of this site are not responsible for content on the site you are about to enter. Patients in the study may take other drugs besides Prolia and Calcium. 12 Low serum calcium levels should be corrected before starting denosumab; supplemental calcium and vitamin D is required in patients predisposed to hypocalcaemia (see Ensure adequate calcium and vitamin D intake ).
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